Exercise Replacement Pill – GW501516

Exercise Pill GW501516An experimental drug that is capable of helping mice to run on a treadmill for 70% longer before becoming exhausted might be used to develop a tablet that provides the same effects as exercise.

Although things that work for mice do not always work for humans, the researchers at the Salk Institute (USA), are so confident of the drug’s potential they are presently looking for a pharmaceutical company to help them do human tests and, hopefully, produce an exercise replacement tablet in the future.

All of the mice used in the study had a sedentary lifestyle and were only normally capable of running in a treadmill for 2 hours 40 minutes. However, when some of the mice were given the drug they managed to keep running for 4 hours 30 minutes.

The drug is called GW501516. It was developed during the 1990s, but was dropped by its creators when it was discovered it may cause dangerous side effects. However, its performance boosting abilities make it very attractive to some athletes and it is presently available to buy illegally, on the black market.

Exercise pillGW501516 activates a gene called PPARD that is associated with the ability to run long distances. It also appears to alter insulin sensitivity and prevent weight gain. These are all capabilities that are normally associated with exercise and physical fitness.

One of the researchers, Dr Weiwei Fan, said: “Exercise activates PPARD, but we’re showing that you can do the same thing without mechanical training. It means you can improve endurance to an equivalent level to someone in training without the physical effort.”

Dr Fan’s colleague, Professor Ronald Evans is equally enthusiastic about the idea of creating an exercise tablet. “It’s well known that people can improve their aerobic endurance through training,” Evans said. “The question for us was: how does endurance work? And if we learn to really understand the science, can we replace training with a drug?”

As people start to attain a greater level of physical fitness, their muscles start to burn more fat and less blood sugar. It is believed the PPARD gene is involved in the process.

Exercise Pill canadaHowever, although burning fat is a desirable benefit dieters will appreciate, the brain prefers the energy provided by sugar. This explains why long-distance runners “hit the wall” and become confused.

According to the researchers, as people become more used to exercise their body adapts by prioritizing the use of sugar to power mental function, while the muscles burn fat instead.

The study was published in the journal Cell Metabolism (02-05-2017) and was inspired by previous research into the relationship between exercise and endurance.

Although an exercise tablet could easily be misused by athletes hoping for an edge over their competitors, and could also be used by unscrupulous horse trainers, it could offer hope to people who are seriously overweight but cannot exercise due to health restrictions or old age.

If it is ever created, an exercise tablet may be of particular value to people who have heart conditions and need to lose weight, but have to be careful about overdoing things.

In a statement, the researchers said: “The team can envision a number of therapeutic applications for a prescription drug based on GW501516, from increasing fat burning in people suffering from obesity or type 2 diabetes to improving patients’ fitness before and after surgery.”

However, some medical experts are not convinced using GW501516 to create an exercise tablet is a good idea. Ali Tavassoli, professor of chemical biology at Southampton University, said, “Someone with obesity or diabetes could be taking a pill for 40 or 50 years. What happens when you take a drug like this for that long? I can’t see these things getting regulatory approval.”

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Hydro-Lyn Review – What Is In It, Side Effects, Stockists

Hydro Lyn CanadaHydro-Lyn is a diet pill you can buy online, but won’t find in any pharmacies or shops.

Buying diet pills online has its advantages because there is no need to make a snap decision.

There is plenty of time to read the supplement facts and do a little research if necessary.

However, some diet pill manufacturers provide so little information about their products, dieters are unable to do any research.

That’s the case with Hydro-Lyn, the product description is only one sentence long and contains no useful information at all.

Hydro-Lyn Benefits

The Hydro-Lyn sales page provides a picture of the front of the bottle and the label states the pills provide three main benefits:

  • Accelerates the metabolism
  • Controls the appetite
  • Increases fat loss by 100%

How Does Hydro-Lyn Work

Like the majority of diet pills, Hydro-Lyn is designed to suppress the appetite and boost the metabolism.

This should allow people to eat less food without feeling hungry. When the food intake is reduced the body get less calories and, if it does not have enough calories to give it the energy it needs, the body will start to burn fat instead.

The metabolism controls the speed at which calories are used. Diet pills that boost the metabolism make the body burn calories faster and this will further increase the need to burn fat instead. However, the claim that Hydro-Lyn increases fat loss by 100% is ridiculous.

If someone was losing one pound of fat a month and they then began losing two pounds per month, fat loss would have been increased by 100%, but the increase would be negligible.

If someone was losing 25 pounds of fat per month, a 100% increase could only be achieved if their fat loss was increased to 50 pounds per month. Even top-rated diet pills like PhenQ would be incapable of delivering such an increase.

Hydro Lyn canada

List of Ingredients

Nutrition Labz does not provide any information about the ingredients used in the product. Presumably this will be printed on the label, but customers can only buy this product online and will not be able to take a look at the label until they are holding the bottle in their hand.

Then if they notice the formulation contains something they know to be dangerous or that they are allergic to, or do not tolerate well, they will be unable to use the pills and a refund will not be available because there is no guarantee.

How to Use Hydro-Lyn

In keeping with the general lack of information regarding this product, the usage guidelines are hazy at best: “1 cap once daily before or after breakfast”.

Hydro-Lyn Customer Testimonials

We were only able to find one customer review for this product and the reviewer had awarded it five stars. The big problem is it was posted on the product sales page. Reviews that are supplied by manufacturers are apt to be biased, so they are best taken with a dose of salt.

Even if the review is genuine, one person’s experience with a product is not enough to provide a genuine insight into the benefits it can provide and/or the side effects it may cause.

Hydro-Lyn  Side Effects

Nutrition Labz claim Hydro-Lyn has been subjected to clinical trials that have shown “it is safe and has no side effects, no rebound, or diarrhea”, but they fail to provide any proof to back this up.

Without an indication of where and when the trials were conducted, and by whom, it’s just a lot of hot air. The truth of the matter is, this product could contain anything.

There is no way of knowing what’s inside the pills because Nutrition Labz fails to supply a list of ingredients. Bearing this in mind, we suggest all potential users ask their doctor’s opinion before using this product.

Manufacture and Distribution

Hydro-Lyn is one of a number of dietary supplements brought to market by Nutrition Labz. We were unable to find out anything about the company at all.

It could be that they manufacture their own products, but it is also possible they are only a distributor of re-branded supplements obtained from a manufacturer that provides white label products.

Product Pricing and After-Sales Service

There are 30 capsules in a bottle of Hydro-Lyn and the cost per bottle is $64.99. There is no money back guarantee, and customer services are only available via an online form and Facebook chat.

The Final Judgment

Hydro-Lyn is an expensive product, there is no proof that it can do anything the manufacturer says it will and, if it does not, a refund won’t be on the cards.

The lack of an ingredient profile means there is no way customers can ascertain if the product is likely to make them feel ill. There is no way on earth we could recommend Hydro-Lyn, so we suggest people who need to lose weight consider using one of the products from our list of approved diet pills instead.

All of them are produced by reputable manufacturers, have good customer reviews, are considerably cheaper than Hydro-Lyn, and are backed by a money back guarantee.

Click here to see which diet pills are high rated and most popular

PhenMax375 – A Phen375 Pale Imitation

Phenmax375 CanadaPhenMax375 is a fat burning diet pill made in America by YoungYou Corporation.

According to the marketing material, it presents a “brand-new approach to thermogenic weight loss” and uses potent ingredients to deliver fast weight loss and decrease the waist circumference.

However, it’s hard to see what this new approach is because all the ingredients used in the PhenMax375 formulation are diet pill regulars.

Another point of interest is that it sounds very much like Phen375 – the market leading dual action fat burner and appetite suppressant.

Advertised Benefits

  • Super thermogenic high energy formula
  • Helps to burn fat all day long
  • Helps take your your weight loss to the max
  • Helps regulate hunger
  • Reduces your daily calorie intake
  • Boosts energy by increasing natural fat metabolism and hormones
  • Works well for both men and women

What is PhenMax375 and How Does it Work? 

PhenMax375 is primarily designed to function as an appetite suppressant and fat burner. It’s also intended to provide extra energy. This is something most dieters will be in need off, especially if they are spending a lot of time at the track or in the gym.

YoungYou don’t provide any information about how any of the promised benefits are likely to be achieved and the formulation does not appear to have been independently tested, so there is no proof that it will work.

However, if it can do the things it’s supposed to do, PhenMax375 should make it easier for dieters to stick to their calorie controlled diets, while also ensuring they burn their stores of fat to get extra energy.

Key Ingredients

All of the ingredients used in PhenMax375 are housed in a proprietary blend (765mg). No inclusion rates are provided, but two capsules contain:

  • B-Phenylethylamine HCL: An organic compound that’s alleged to be good for boosting energy levels and supporting weight loss, but there is a lack of scientific evidence to support such claims.
  • Garcinia Cambogia Extract: A tropical fruit that provides hydroxycitric acid (HCA). This chemical has the ability to prevent new fat cells from forming. It also appears to be good for curbing hunger urges.
  • L-Carnitine Fumarate: Provides the amino acid L-carnitine, which helps the body produce energy. It’s also credited with many other abilities, but offers the most value to people who are L-carnitine deficient.
  • Caralluma Extract: A respected appetite suppressant that’s obtained from a species of cactus. It’s ability to take away hunger was put to the test by researchers in India and it’s hunger suppressing reputation appears to be built on solid ground. However, the study participants were given 1g of caralluma per day. The amount provided here is much less. The PhenMax375 proprietary blend is 765mg and Caralluma shares capsule space with five other ingredients.
  • Green Tea: A proven metabolism booster and thermogenic fat burner, green tea is also an extremely healthy ingredient that may protect the heart from the damage caused by heart attacks and strokes.
  • Guarana: A berry extract that provides caffeine. Guarana is good for providing long term energy, so the fact that it’s often added to energy drinks should not come as a surprise. Caffeine is a proven fat burner, so the presence of guarana in the formulation may also help provide some of the promised weight loss.
Usage Instructions – has to taken with a large glass of water, within 20 minutes of eating breakfast, and a healthy eating plan and regular exercise are recommended. Unfortunately, YoungYou appear to be confused about the dose. The marketing material on their website states only one pill is required per day. The back of the bottle says it’s two.

Customer Feedback

Customer feedback is a mix of good and bad.

A few average PhenMax375 customer reviews read:

“Decreased my hunger and helped me to lose 7 pounds in 14 days. No side effects.”
“I used this product for 8 weeks and it didn’t do a thing. What a load of crap!!!”
“Gave me plenty of energy and curbed my appetite too.”
“I’m sorry to say this didn’t work for me. Absolutely no results at all.”

PhenMax375 Side Effects & Health Issues

YoungYou stress the importance of seeking medical advice prior to using any brand of dietary supplement.

Where To Buy PhenMax375

It’s Possible to buy PhenMax375 from the manufacturers website and from Amazon. Each bottle contains 60 capsules. Customers who buy via Amazon can expect to pay around $26 per bottle. Buying directly from the manufacturer will bring the price down to $22.50.

Guarantee

There is no money back guarantee.

The Bottom Line

Although the formulation contains some good ingredients, the inclusion rates may be too low to provide adequate results and customer feedback suggests it does not work for many users.

This is not a point in the product’s favor because anyone who is disappointed by PhenMax375 will be unable to get their money back. At this point it’s worth mentioning PhenMax375 is a copycat product intended to attract the attention of people hoping to buy one of the most respected diet pills in the world—Phen375.

Phen375 real reviewThe name PhenMax375 even suggests it may be a higher strength version, but it’s not, and Phen375 is only available from Phen375.com. It’s not made by YoungYou, but it does have a money back guarantee and plenty of good customer reviews.

PhenMax375 is slightly cheaper, so it beats it as far as the price goes, but will be unable to match it in results and, when it comes to weight loss, it’s the results that count.

Click here to read the Phen375 review and compare

Ionamin Review – Prescription Diet Pill With Phentermine

Ionamin canadaIonamin is a prescription medication that contains the drug Phentermine. It’s made in America by Celltech Pharmaceuticals, comes in the form of yellow capsule, and is intended to offer dieters short term support to help them lose weight.

It’s proved to be effective for many people, but Ionamin does not work for everyone and people who don’t appear to be making progress will find their doctor stops writing them prescriptions sooner than normal.

Although Ionamin has value as a weight loss aid, it does not compare well to some of the best over-the-counter diet pills. For one thing, doctors only prescribe it to people who are dangerously over weight.

The usage period is another issue. Most people who need to lose weight will need ongoing support.

A few weeks just will not cut it. However, by far the biggest problem with this particular prescription weight loss medication is the negative effects it can have on the health.

Ionamin can cause numerous side effects and even poses a threat of addiction. So, if you think the fact that Ionamin is only issued with a prescription is an endorsement of its power, you may want to think again. It’s prescription-only status is more probably due to the fact that its use requires close supervision by a medical expert.

How Ionamin Supports Weight Loss

Ionamin PhentermineIonamin has the ability to control hunger. When people are making a committed effort to eat less food, one of the hardest thing to do is cope with the hunger pangs this causes.

These can be very bad. Especially during the early stages of a diet. Many dieters find it’s their hunger that controls them in the end, give in, and watch their good intentions go up in smoke.

By suppressing the urge to eat, Ionamin makes it easier for dieters to maintain their focus, stick to their calorie controlled diets, and create the calorie shortage that is needed to encourage the body to begin burning its fat.

Key Ingredients and Blend Potential

Ionamin only contains Phentermine. There are no other active ingredients. The amount of Phentermine provided will be either 15mg or 30mg, depending on which strength option your doctor has prescribed for you.

Phentermine belongs to a class of drugs called psychostimulants and it has the ability to stimulate the hypothalamus area of the brain and trick it into triggering secretions that would only normally be released during times of danger.

When the life is at stake any distractions may be fatal, and feelings of hunger can be very distracting, so one of the things the secretions do is suppresses the desire to eat.

This inbuilt hunger control mechanism is only one of several changes that occur in the body during times of danger and is part of a response that this known as flight or fight.

Usage Guidelines  – Only one pill is required per day. It should be taken 10 to 14 hours before bedtime. It’s important to swallow the pill whole. If you crush it or chew it you will get too much Phentermine too soon and will be more likely to experience negative issues.

Ionamin User Comments

“Ionamin worked okay and I was starting to lose weight, but it often made my hart start pounding like a drum and it was so frightening I stopped taking the pills in then end.”
“This medicine made me feel so unwell my doctor stopped prescribing it and told me to stop taking it at once. I was happy to do as I was told.”
“I found I was not so hungry while I was taking these pills and lost 24 pounds in three months. Made me a little sick and dizzy sometimes, but worth it in the end.”
“These yellow devils helped me to drop a couple of dress sizes, but I became addicted to them and ended up moving on to speed. Everything is okay now, but it took a lot of counselling to sort things out.”

Ionamin Side Effects & Health Considerations

Ionamin stimulates the central nervous system in a similar way to amphetamine and can be just as addictive. It also has the potential to cause a number of side effects.

This is not a complete list, but Ionamin side can include:

  • Dizziness
  • Dry mouth
  • Headaches
  • Changes in bowel function
  • Sleep problems
  • Irritability
  • high blood pressure
  • Pounding heartbeat/palpitations
  • Muscle twitches
  • Mood swings
  • Hallucinations
  • Loss of interest in sex
  • Allergic reaction

Where to Buy Ionamin

You can buy Ionamin from your local pharmacy, but only if you go in bearing a doctor’s prescription.

Guarantee

Although the best over-the-counter diet pills are sold with a money back guarantee, prescription medications are not.

The Verdict

Ionamin offers dieters a way to control hunger urges, but it does not provide the long-term support most dieters will need and its use presents many problems, including side effects and the possibility of addiction.

These are problems that are common to all brands of Phentermine and it’s one of the reasons so many supplement manufacturers have developed Phentermine substitute products.

PhenQThe best Phentermine replacement so far is called PhenQ and it’s powered by a blend of natural ingredients that does not have a reputation for causing side effects, but does have one for getting results.

Customer reviews are excellent, and PhenQ is even sold with a 60-day money back guarantee, so it beats Ionamin in every way.

Click to read why customers prefer PhenQ

High School Genes Review – Gwyneth Paltrow Goop

High School Genes CanadaHigh School Genes Review. Periods are not a pleasant thing but women have to learn to live with them on a monthly basis from puberty onwards.

The female period is controlled by hormones and can cause a lot lot of unpleasant symptoms including swollen breasts, acne, and bloating.

Fortunately the problem goes away after menopause, but the hormonal changes that take away the need to bleed also present other issues and can retard the metabolism sufficiently to cause weight gain.

High School Genes is a dietary supplement designed to rectify this problem, get the metabolism back on track and help rid the body of excess fat.

Who Makes High School Genes?

High School Genes is made by Goop and marketed as part of the Goop Wellness range of products. The company was founded by the actress Gwyneth Paltrow and has been trading since 2008.

Who Makes High School Genes?

A few of the company’s other lines include Goop clothing, bags, shoes, and accessories.

There are even Goop fragrances and beauty products. Needles to say, Paltrow is not qualified to formulate fragrances and beauty creams etc., so she needed to recruit some expert help.

The Goop Wellness products are designed by doctors and the doctor who created High School Genes, Sara Gottfried, M.D, is a recognized hormone expert.

What Kind of Supplement is High School Genes?

High School Genes consists of five tablets and a capsule that are intended to be taken together. Only one (6-pill) dose is required each day and there is no need for fiddling with several bottles or boxes because the pills are packaged into handy little single dose envelopes.

Each envelope contains:

  • 2 x Metabolism Boosting Tablets
  • 1 x PhytoBlend Multi tablet
  • 1 x Omega-3 EPA-DHA 1000 Capsule
  • 1 x Free Radical Scavenger Tablet
  • 1 x Gut Balance Tablet

The Goop website does not provide any information about the roles each pill is expected to play but guessing the function of the Metabolism Boost tablets is hardly rocket science. The Free Radical Scavenger tablet probably contains antioxidants that can rid the body of toxins, and the Gut Balance tablet may be intended to provide a detox. As for the rest, we cannot really say.

What Kind of Supplement is High School Genes?

Is High School Genes Suitable For All Women?

One of the ingredients is Rhubarb. It’s good for keeping people regular, but its use may lead to abdominal crams and diarrhoea. High School Genes also contains taurine and caffeine. Both can clear the mind and boost energy levels, but their presence could be a problem for anyone who does not tolerate stimulants well.

High School Genes is not a good option for women who are pregnant or nursing a child. Women who have existing health problems, or are using medicines, should get a doctor’s advice before they commence supplementation.

Usage Instructions – The six pills are taken with water in the traditional way, but some women will not be used to taking so many pills together or in close succession.

What are the Promised Benefits?

Goop does not provide a clear picture of the likely benefits, but the main selling points appear to be:

  • Vitamin and mineral support
  • Boosted metabolism
  • Improved calorie burning
  • Improved cellular health
  • Supports normal glucose levels

What are the Ingredients?

There are a lot of vitamins and minerals, often in very high doses that far exceed the recommended daily amount.

The product also provides Omega 3 fatty acids and numerous plant extracts, including watercress, Chinese cinnamon, green tea, and several fruit extracts. Some of the fruit extract, including blueberry, may provide antioxidants that will help purge the body of free-radical toxins.

And the B Vitamins provided should help boost the metabolism and improve cellular health. Green tea is a proven fat burner and there is also some zinc and Iodine. Both these minerals have roles to play in hormone production, so their presence is appropriate for a product that is intended to manipulate hormone levels.

However, these are just a few of the ingredients. There are around 50 in total and it is not possible to predict how such large combination of ingredients is likely to perform when grouped together in this way.

What About the Price?

High School Genes is a reasonably expensive product. Customers who buy it are looking at paying $75 (£57.50) to $90 (£69) per month, depending on whether they opt to buy as a one-off transaction or purchase via auto-ship. The latter is the cheapest option. It’s also worth taking note of the fact that Goop does not offer a money back guarantee.

Where Can I Buy High School Genes?

You can only buy High School Genes if you are based in the USA because Goop has stopped providing international shipping options and the official website is the only place to go.

Will the Product Do the Things it’s Supposed to Do?

Menopausal women have a lot of adjusting to do and it is possible that some of the ingredients provided by High School Genes may help ease the transition period.

The presence of green tea and some of the other ingredients may boost the metabolism and encourage the body to start burning fat instead of storing it.

PhenQThere is no proof that this six-pill combo will work though, and some of the vitamin inclusion rates are high enough to be concerning. If you are reading this because you are looking for a way to lose excess weight, we suggest you buy PhenQ instead.

The product has far fewer ingredients, but all of them have proven value. It is also much cheaper and comes with a 60-day money back guarantee.

Read why PhenQ is so highly rated