Exercise Replacement Pill – GW501516

Exercise Pill GW501516An experimental drug that is capable of helping mice to run on a treadmill for 70% longer before becoming exhausted might be used to develop a tablet that provides the same effects as exercise.

Although things that work for mice do not always work for humans, the researchers at the Salk Institute (USA), are so confident of the drug’s potential they are presently looking for a pharmaceutical company to help them do human tests and, hopefully, produce an exercise replacement tablet in the future.

All of the mice used in the study had a sedentary lifestyle and were only normally capable of running in a treadmill for 2 hours 40 minutes. However, when some of the mice were given the drug they managed to keep running for 4 hours 30 minutes.

The drug is called GW501516. It was developed during the 1990s, but was dropped by its creators when it was discovered it may cause dangerous side effects. However, its performance boosting abilities make it very attractive to some athletes and it is presently available to buy illegally, on the black market.

Exercise pillGW501516 activates a gene called PPARD that is associated with the ability to run long distances. It also appears to alter insulin sensitivity and prevent weight gain. These are all capabilities that are normally associated with exercise and physical fitness.

One of the researchers, Dr Weiwei Fan, said: “Exercise activates PPARD, but we’re showing that you can do the same thing without mechanical training. It means you can improve endurance to an equivalent level to someone in training without the physical effort.”

Dr Fan’s colleague, Professor Ronald Evans is equally enthusiastic about the idea of creating an exercise tablet. “It’s well known that people can improve their aerobic endurance through training,” Evans said. “The question for us was: how does endurance work? And if we learn to really understand the science, can we replace training with a drug?”

As people start to attain a greater level of physical fitness, their muscles start to burn more fat and less blood sugar. It is believed the PPARD gene is involved in the process.

Exercise Pill canadaHowever, although burning fat is a desirable benefit dieters will appreciate, the brain prefers the energy provided by sugar. This explains why long-distance runners “hit the wall” and become confused.

According to the researchers, as people become more used to exercise their body adapts by prioritizing the use of sugar to power mental function, while the muscles burn fat instead.

The study was published in the journal Cell Metabolism (02-05-2017) and was inspired by previous research into the relationship between exercise and endurance.

Although an exercise tablet could easily be misused by athletes hoping for an edge over their competitors, and could also be used by unscrupulous horse trainers, it could offer hope to people who are seriously overweight but cannot exercise due to health restrictions or old age.

If it is ever created, an exercise tablet may be of particular value to people who have heart conditions and need to lose weight, but have to be careful about overdoing things.

In a statement, the researchers said: “The team can envision a number of therapeutic applications for a prescription drug based on GW501516, from increasing fat burning in people suffering from obesity or type 2 diabetes to improving patients’ fitness before and after surgery.”

However, some medical experts are not convinced using GW501516 to create an exercise tablet is a good idea. Ali Tavassoli, professor of chemical biology at Southampton University, said, “Someone with obesity or diabetes could be taking a pill for 40 or 50 years. What happens when you take a drug like this for that long? I can’t see these things getting regulatory approval.”

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Best Appetite Suppressants – Canada and USA

Appetite suppression can play a key role in any successful weight loss program. Although some people are strong enough to fight their hunger urges and go it alone, many are not and there is no need to feel ashamed if you need a little extra help to stick to your calorie-restricted diet.

If you are looking for an appetite suppressant these days, you will be spoiled for choice. There are a lot of options available, but many of them are lacking in power or simply do not work at all. However, there are a few that can deliver the goods, and do so without causing side effects, and five of them stand head and shoulders above the rest.


PhenQPhenQ’s reputation as an appetite suppressant is probably mostly thanks to the nopal content. Nopal is a cactus extract that has been used as an appetite killer for hundreds of years.

Scientists have yet to define the way nopal works on the appetite but it has been speculated its abilities may be due to one or more of the many amino acids that are included in its makeup.

More recently, scientists have discovered nopal also functions as a fat blocker. This makes it doubly valuable because every gram of fat eaten would normally provide the body with nine calories.

Nopal’s ability to shield dietary fat from the digestive enzymes can make a big difference to a calorie controlled diet and help lower the daily calorie intake considerably.

The fat blocking ability of nopal offers a rather interesting bonus because the presence of the blocked fat inside the digestive organs can create a feeling of satiety that causes the brain to cancel the signals it was sending the body to encourage it to eat.

What do PhenQ customers really think – click here


Phe375 fat burning supplementA best-selling diet pill that has been around for a long time. It may no longer be the market leader, but Phen375 is still way ahead of the pack and has been such a successful product, for so many years, some of the less scrupulous diet pill manufacturers have come up with copy-cat products that have a similar bottle but are incapable of providing the same intensive weight loss support as the real Phen375.

However there is no need to be fooled. The genuine product is only available from the official website. If you see it for sale elsewhere you’re looking at a fake.

The hunger suppressing ability of Phen375 is no secret. A lot of people have lost a lot of weight with this product and done so without feeling hungry. The manufacturers have sold over 200,000 bottles and customer reviews are excellent.

With a name like “Phen375”, it’s pretty clear this diet pill is intended to be a safe and legal alternative to the prescription appetite suppressant Phentermine. The pills even mimic Phentermine by duplicating its white with blue specks look. It’s more than just an appetite suppressant though. Phen375 can further assist weight loss by increasing the metabolism and helping you to burn fat.

What do customers think of Phen375 – click to find out

Proactol XS

Proactol XSProactol XS is a good appetite suppressant that some dieters may overlook because it’s primarily marketed as as fat blocker. A gram of fat provides nine calories, so any good fat blocker that works in the promised way can be very useful for reducing the amount of calories the body receives each day.

The fat blocking action of Proactol XS is provided by chitosan. The body cannot absorb chitosan, but chitosan can absorb the dietary fat it encounters in the digestive system and, by doing so, chitosan makes the fat indigestible too. The presence of the resulting chitosan-fat compound provides a feeling of satiety and the appetite is suppressed.

Unfortunately, some of the people who don’t overlook Proactol XS may still be tempted to avoid it. Even those who are aware of how good an appetite suppressant it can be.

Most diet pills that contain chitosan use the type that is taken from sea-living crustaceans. This is unsuitable for people who are vegetarian or allergic to seafood. However, the chitosan used in Proactol XS does not present such problems because its obtained from a species of fungus and is known to be more powerful than the other form.

Can Proactol XS really help you lose weight – click here


Like many of the best appetite suppressants, Phentaslim is a versatile diet pill that covers several bases and is good for helping dieters to lose weight quickly.

At the time of this review Phentaslim had succeeded in impressing over 100,000 customers. Due to the fact that it is so cleverly named, a lot of people who buy the pills have discovered them because they were searching for a way to buy Phentermine online.

The prescription only drug Phentermine is an appetite suppressant that is often seen as being the be all and end all when it comes to weight loss, but it’s abilities are incredibly overrated and many former Phentermine users who have switched to Phentaslim say Phentaslim offers superior results.

The strong appetite suppression provided by Phentaslim is partly due to its caffeine content. Caffeine has proven hunger curbing abilities and it gets to work fast.

There is some guarana in the formulation as well. It provides caffeine too, but does so more slowly so the benefits can go on for extended periods of time. However Cayenne is probably the main appetite suppressor because it provides capsaicin. Science shows that it works and it’s also a powerful fat burner.

Can Phentaslim really help you lose weight – click here

Gravitate Supersculpt

Supersculpt CanadaSupersculpt is an appetite suppressant created by the folks over at Gravitate Nutrition. The only other product they sell is a nutritional supplement called DietVits and it’s intended to be used alongside Supersculp.

This is not a bad idea because anyone who is eating less food to lose weight may also be failing to get all of the vitamins and minerals they need.

DietVits is a quality product that should be able to pick up the slack and some of the inclusions are likely to help speed up weight loss. B Vitamins are good for the metabolism, and chromium balances insulin levels and can help prevent the after-meal sugar spikes that can trigger a desire for sweet food.

The reason Gravitate Supersculp is such a good appetite suppressant is due to its simple formulation that consists of one scientifically proven ingredient.

It’s called glucomannan and its highly absorbent nature allows it to soak up water inside the stomach and then expand to form a gelatinous mass that fills the stomach cavity and makes it feel pleasantly full. When the stomach feels full it signals the brain and the brain responds by dulling the desire for food.

The other impressive thing about Supersculp is the dose. Two pills provide 1,000mg, and the European Food Safety Authority confirm this is the amount that is needed to get the best results.

Read more detail on Gravitate here


Best Diet Pills For 2017 – Best Fat Burners, Fat Blockers and Appetite Suppressants

Diet Pills for womenWhat are the best diet pills to buy in 2017? If that’s what you are asking yourself you are not alone, but finding the best of the best is not an easy chore – there are many products on the market each with it’s own weight loss angle.

Diet pills – or the mechanics of actions of diet pills can be split into three distict major categories: fat burners, fat blockers or fat binders and appetite suppressants. Those with more than one mechnic of action are the products to considered more closely that the one function products.

Here are the current top diet pills that customers from the USA, Canada, Australia and the UK are buying.

PhenQ – Multi Action Fat Burner

PhenQWe picked this product last year and we’re picking it again. It’s a multi-action diet pill that’s a fat burner, fat blocker, and appetite suppressant rolled into one.

It also has the ability to improve the mood and boost energy levels; so dieters who decide to lose weight with PhenQ need have no fear their new healthy lifestyle will leave them feeling blue or overly tired. Nor will they need to worry about having to constantly battle hunger pangs. Thus far, we’ve never encountered a product that offers dieters better all around support.

The pills are easy to swallow, past customers agree the formulation works, and many people say the pills are particularly effective for burning unwanted body fat that as accumulated in troublesome areas such as the waist, upper arms, and thighs.

Buying PhenQ is easy. It has its own official site and the manufacturer provides free shipping to addresses anywhere in the world. It also comes with a 60-day money back guarantee.

Read the Full Review Here

Phentaslim – Fat Burner, Workout Supplement

Phentaslim top productPhentaslim is a “maximum strength fat burner”. It says so on the bottle and countless customers the world over swear the words are true. Like the other two products that made our list of best diet pills for 2017, Phentaslim has the ability to deliver results and its a top-rated fat burner in many different areas of the world. The fact that it has become such a popular fat burner is not surprising because the capsules contain some of the most respected fat incinerators available, but the pills are no one-hit-wonder.

They are designed to attack problem areas in a number of ways and give dieters the tools they need to ensure their weight loss dreams are realized. Phentaslim is an appetite suppressant that curbs hunger pangs and helps you eat less calories. It increases the metabolism too, enabling you to burn calories faster and get to work on stores of fat. Phetaslim also boosts energy levels, so your diet won’t leave you feeling so dog-tired you want to throw in the towel.

As with many top diet pills, Phentaslim has an official website and it’s the only place to go if you want the genuine product. If you see it elsewhere it’s probably a knock-off product that won’t be capable of matching Phentaslim’s ability to maximize results and deliver the fast, safe weight loss most dieters want. It’s a very worthy addition to our list of best diet pills for 2017, and it comes with a 60-day money back guarantee.

Read the Full Review Here

Phen375 – Fat Burner and Appetite Suppressant

Phe375 fat burning supplementPhen375 is another of our all-time favourite diet pills. It’s a powerful appetite suppressant and fat burner that get the job done. It’s not a new product. It’s been around for a number of years and most dieters who use Phen375 can expect to achieve a weight loss of 3 – 5lbs (1.3 – 2.2kg) per week, though, in all honesty there is no shortage of customer reviews left by people boasting they have lost considerably more. The only problem with Phen375 is, to a certain extent, it has fallen victim to its own success.

The fact that so many people are raving about how good the pills are has encouraged a number of copy-cat products that have names and packaging that are so similar, it is easy to make a mistake and buy the wrong product. The original Phen375 is the best. It’s manufactured in the USA by RDK and has its own official website.

Phen375 is also a safe and legal substitute for Phentermine. It contains pharmacy grade ingredients, but its available with out prescription and, unlike Phentermine, Phen375 can give energy levels a boost. That’s a feature that many dieters will appreciate and one of the best things about Phen375 is there are no known side effects.

Read the Full Review Here

Contrave – what does it do, is it available to buy from a pharmacy

Contrave CanadaContrave is a weight loss medication doctors prescribe as a treatment for their most obese patients. Its use was approved by the American FDA in 2014 and the following year the relevant deciding bodies approved it for use in Europe.

Unlike some of the other weight loss medications doctors have at their disposal, Contrave does not contain one drug. It contains two (Buprion and Naltrexone) and although both drugs are normally used as a treatment for other things, including depression (Buprion) and alcohol dependence (Naltrexone), each of them appears to have the potential to encourage some degree of weight loss and their abilities are increased when they are combined.

How Contrave Works

Contrave is an appetite suppressant that works on the mind rather than the body. Once the drug has been consumed it is transported to the brain, via the blood, targets the areas of the central nervous system that are responsible for controlling hunger levels, and causes changes that suppress the appetite.

Scientific Study

The manufacturer of Contrave conducted a number of clinical trials before the drug was presented to the FDA for approval. The number of study subjects involved totalled 4,500. All of them were obese and some of them had weight-related problems. Others did not. The study period was a year and all of the study subjects were required to maintain healthy eating habits and exercise regularly. When the data was examined the researchers discovered the people who were given Contrave had lost 4.1% more weight than the people who received a placebo. The FDA referred to this study when they announced their approval of the drug in September 2014.

Usage Guidelines – Contrave capsules should always be swallowed whole and it is important not to consume Contrave alongside meals that have a high fat content or while drinking alcohol as doing either of these things can increase the likelihood of seizure.

Although the normal dose is four capsules each day, new users have to build up to that level gradually. For the first week of use only one capsule is allowed per day. This should be taken in the morning. On the second week patients take a second capsule during the evening. The following week the morning dose is increased to two capsules, but the evening dose remains the same. The full dose, of two capsules each morning and two capsules every evening, comes into force from week four onwards.


Not everyone is a good candidate for treatment with Contrave and doctors have to make a decision based on the official guidelines, their patients’ medical history, and any medication that may presently be in use.

The official guidelines state the drug must always be used alongside diet and exercise, so any patient who is not willing to make a serious commitment to make the necessary lifestyle changes will be unable to attain a prescription for Contrave.

The guidelines also state patients must have attained a minimum BMI of 27 (with weight-related health problems) or a BMI of 30 (without weight related problems).

However, Contrave is not suitable for pregnant women, people who suffer from eating disorders, or anyone who has high blood pressure, a history of seizures, or certain other medical problems.

Unfavorable Interactions

Contrave is not compatible with some medications, including sedatives, benzosiazepines, anti-seizure drugs, methadone, and buprenorphine.

Potential for Side Effects

Bearing in mind all the considerations regarding its use, it would be nice if Contrave could offer weight loss without side effects, but that is far from being the case.

A few of the more commonly experienced side effects Contrave users may encounter are:

  • Dry mouth
  • Nausea
  • Vomiting
  • Dizziness
  • Headache
  • Difficulty sleeping
  • Changes in bowel movement

However, less commonly encountered, but more serious side effects, include:

  • Increased blood pressure
  • Severe allergic reaction
  • Increased heart rate
  • Manic episodes
  • Liver damage/hepatitis
  • Suicidal thoughts
  • Visual problems

Other Considerations

Although it is not one of the worst performing prescription only weight loss drugs, neither does Contrave appear to be one of the best. When researchers compared its abilities to Qsymia, Contrave came a poor second because study subjects who received Qsymia showed a 9% reduction in their body weight and the study subjects who were given Contrave only showed a 5% reduction. However, this was still 2% more than the Belviq users managed to achieve.

Diet Pills Available Without Prescription – click here


What Are The 10 Best Fat Burning Ingredients – Natural Fat Burners

Cayenne Pepper – the fat burning power of chili pepper

CapsimaxIf you think cayenne is only useful for spicing up curries and other hot dishes think again. Research shows cayenne also has the ability to elevate the body temperature sufficiently to encourage the release of calories that have been stored as body fat and convert them to heat. This process is known as thermogenic fat burning and several studies prove cayenne has this ability. A patented product called capsimax has been used in the diet industry for the past years that really exploits the power of cayenne pepper Diet pill that has Capsimax powder

After one study, involving 13 female volunteers, the researchers concluded: “These results indicate red pepper increases diet-induced thermogenesis and lipid oxidation.” The results of this and other studies have caused cayenne to become a very popular fat burning ingredient and there is some evidence to suggest the fat burning effects of cayenne may last for up to 24 hours after the ingredient has been consumed.

a-Lacys Reset – retain lean muscle mass

What is A-lacys resetA patented ingredient that provides cysteine and alpha-lipoic acid. It’s a pretty new weight loss ingredient, but it’s also an exciting one because studies show supplementation with a-Lacys Reset can increase weight loss by 3.44% while also offering protection against loss of muscle mass. The dieting process can often result in a slight reduction in muscle mass and this can be particularly worrying for body builders who have invested a lot of time, energy, and money to develop their physiques. Now that a-Lacys Reset has arrived on the scene this worry may become a thing of the past as a-Lacys Reset can help users retain lean muscle mass. PhenQ is the best example

Garcinia Cambogia – super fruit, super fat burner

Garcinia cambogia extractA superfruit ingredient that is super-rich in nutrients, promotes good health, and is well respected for its fat burning abilities.

The active component in garcinia cambogia is a chemical called hydroxycitric acid (HCA). In order to produce good results, products that contain garcinia cambogia need to have a HCA content of 60% or more. When this requirement is met, garcinia cambogia has the ability to accelerate the fat burning process and can further enhance weight loss by suppressing the appetite. Read about Garcinia Cambogia Extra

Green Tea – drink yourself slimmer

Green TeaGreen tea is a healthy ingredient that is packed full of antioxidants and also boasts excellent fat burning abilities. It[s one of the most commonly used diet pill ingredients in the world and its abilities as a fat burner can be supported by countless scientific studies and evaluations.

The results of one study were published in the American Journal of Clinical Nutrition. A European research team wanted to find out if the catechins, caffeine, and polyphenols in green tea could increase 24-hour energy expenditure and fat oxidation. They recruited 10 healthy male volunteers, provided them with green tea supplements or a placebo, and monitored the men closely. At the completion of the study the researchers were convinced of green tea’s ability to burn body fat, but did not attribute this ability to its caffeine content. They concluded: “Green tea has thermogenic properties and promotes fat oxidation beyond that explained by its caffeine content per se.” SuperFruit Slim contains green tea in capsule form

Green Coffee Bean Extract – green beans are natural

Yes coffee can help make you thin, but if you want to burn fat fast it has got to be green. Unless you are drinking decaf, normal coffee can assist weight loss because it contains caffeine, but green coffee beans burn fat faster because they contain something normal coffee beans do not. It’s called chlorogenic acid and, although all coffee beans possess it while they are still in their natural state (green), the chemical is lost when the beans are roasted to give them more flavour.

The results of a study conducted in 2012, show supplementation with green coffee bean extract can facilitate substantial weight decreases in a short period of time. The study ran for 22 weeks and the researchers recorded an average body fat decrease of 16%. That’s not at all bad for a humble coffee bean.

Raspberry Ketone – A Dr Oz inspired superfruit

what is raspberry ketoneCan raspberries help you lose weight? If you are eating them bowl after bowl it is highly unlikely. The fruit only contain a small quantity of the fat burning phenol that is marketed as raspberry ketone. This is a fact that makes raspberry ketone very expensive to produce, but the ingredient is a powerful fat burner and some people say it has helped them to lose up to 5 pounds per week.

The fact that the ingredient has such value as natural fat burner would probably have remained largely unknown had it not been for the American weight loss expert and TV personality, Dr OZ, who described raspberry ketone as a “miracle fat burner” during one of his shows. However, some manufacturers use synthetic raspberry ketone that has been created in a lab. It’s a cheaper option, but the results are not nearly as good, so dieters need to remember real raspberry ketone is best. Raspberry Ketone diet pill

Caffeine – more than just coffee

Many people think caffeine is only added to diet supplements because it helps prevent diet-related fatigue. This is far from being the case. Researchers in Denmark have collected data that shows caffeine is a thermogenic fat burner. The fat burning abilities of caffeine have also been put to the test in laboratories and research establishments all over the world and the claims that are made about the ingredient’s ability to promote weight loss continue to bear up to scientific scrutiny

Acai Berry – also strong anti oxidant

Acai berries are often refereed to as the healthiest fruit in the world. They are packed with antioxidants and highly nutritious, so the claim could be true, but if you are reading this you are probably more interested in the fat burning ability of acai. Superfruit Slim also contains Acia

Like raspberry ketone, acai ‘s popularity as a fat burner is largely built on an endorsement from Dr Oz. However, there seems to be some confusion over how the ingredient works. Some experts believe it’s prowess stems from its ability to boost overall health and fitness and help the body to do what it is designed to do. This is not an unreasonable idea, but many dieters may be more interested in the end result than how it cam about. Especially bearing in mind the fact some people claim supplementation with acai has allowed them to lose up to 20lbs in just one week.

Citrus Aurantium – A citrus fruit with a kick

Citrus aurantium is a species of citrus fruit that provides a fat burning chemical called synephrine. The ingredient is also sometimes called bitter orange and its ability to deliver good weight loss results in a relatively short period of time has resulted in the ingredient becoming very popular with dieters and diet pill manufacturers alike. The fat burning powers of citrus aurantium have been well researched and a review of the studies to date suggests its reputation as a fat burner is not without good reason.

African Mango – The first Dr Oz inspired fat burner

African mangoAnyone who is searching for the best fat burner should never overlook the abilities of African Mango. It’s a tropical fruit that is high in fibre and nutritional value. It is also a very good choice for people who have tolerance issues that necessitate the need for a stimulant-free fat burner.

The results of one study, published in the journal Lipids in Health and Disease is highly supportive of the fat blasting powers of African mango and suggests it may also have the ability to keep cholesterol levels under control. The study period was 10 weeks and 102 overweight individuals took part. Each of them were given daily doses of African mango (150mg) or a placebo. At the end of the study the African mango group had lost 6.3% more body fat than the placebo group. They dont call it Superfruit Slim for nothing